Phenacetin o-deethylation
WebPhenacetin O-deethylation is a marker reaction of CYP450 1A2 activity. The drug-metabolizing enzyme is constitutively expressed in liver. In this study, an in vivo rat model … WebMar 24, 1993 · The present study demonstrates that fluvoxamine is a very potent inhibitor of the high-affinity O-deethylation of phenacetin, which is catalysed by cytochrome …
Phenacetin o-deethylation
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WebMolecules 2011, 16 6592 Keywords: corydaline; cytochrome P450 inhibition; UDP-glucuronosyltransferase inhibition; human liver microsomes; drug-drug interaction 1. Introduction Corydalis tubers, the roots of Corydalis yanhusuo W.T. Wang, have long been used as an herbal drug for their analgesic and anti-ulcer effects [1-3]. WebJun 1, 2001 · Phenacetin O -deethylation (CYP1A2), coumarin 7-hydroxylation (CYP2A6), diclofenac 4′-hydroxylation (CYP2C9), omeprazole 5-hydroxylation (CYP2C19), dextromethorphan O -demethylation (CYP2D6), 7-ethoxy-4-trifluoromethylcoumarin deethylation (CYP2B6), p -nitrophenol hydroxylation (CYP2E1), and omeprazole …
WebThe in vitro inhibitory effects of gemfibrozil on cytochrome P450 (CYP) 1A2 (phenacetin O-deethylation), CYP2A6 (coumarin 7-hydroxylation), CYP2C9 (tolbutamide hydroxylation), CYP2C19 (S-mephenytoin 4'-hydroxylation), CYP2D6 (dextromethorphan O-deethylation), CYP2E1 (chlorzoxazone 6-hydroxylation), and CYP3A4 (midazolam 1'-hydroxylation) … WebCorrelation analysis For correlation analysis, microsomes from 25 livers were employed with respect to activities of 6-MNA formation (50 μM of nabumetone) and index reactions for CYP1A2 (phenacetin Downloaded from dmd.aspetjournals.org at ASPET Journals on January 12, 2024 O-deethylation), CYP2A6 (coumarin 6-hydroxylation), CYP2B6 …
WebExpressed CYP1A1 and CYP1A2 both catalyzed the O-deethylation of phenacetin, although the apparent Km was about 4-fold lower for CYP1A2 (25 vs. 108 microM). Phenacetin O … Webjaceosidin potently inhibited CYP1A2-catalyzed phenacetin O-deethylation with 50% inhibitory concentration (IC50) values of 9.4 μM and 5.3 μM, respectively, and CYP2C9-catalyzed diclofenac 4-hydroxylation with IC50 values of 4.1 μM and 10.2 μM, respectively. Eupatilin and jaceosidin were also found to moderately inhibit CYP2C19-catalyzed [S]-
WebPhenacetin O-deethylation is the preferred probe reaction for CYP1A2, in which the metabolite, acetaminophen, is quantified using liquid chromatography-tandem mass spectrometry. DMSO was found to inhibit CYP1A2-mediated phenacetin O-deethylation even at low concentrations (0.1%).
WebIn previous studies, the oxygen deethylation metabolism of phenacetin is often used to reflect the activity of CYP1A2. However, due to the potential toxicity of phenacetin, this … the sims 4 high school years graduate earlyWebJun 13, 2012 · Phenacetin is primarily metabolized to acetaminophen via O-deethylation, although the formation of a minor metabolite acetol (∼5%) via acetyl hydroxylation has … my wifi testWebSep 1, 1981 · Abstract. Human and rat liver microsomal fractions exhibit non-linear Michaelis-Menten kinetics in the O-deethylation of both phenacetin and 7 … my wifi strengthWebBiotransformation of phenacetin via O-deethylation to acetaminophen, an index reaction reflecting activity of Cytochrome P450-1A2, was studied in microsomal preparations from … my wifi tv apk firestickWebJun 15, 2012 · Phenacetin O-deethylation is a marker reaction of cytochrome P4501A2 (CYP1A2) activity. In this study, our aim is to investigate whether phenacetin O … my wifi tv apk downloadWeb开馆时间：周一至周日7:00-22:30 周五 7:00-12:00; 我的图书馆 my wifi shows no internet accessWebPhenacetin O-deethylation catalysed by human liver microcomes has been examined over a substrate concentration range of 2.5 to 700 microM using preparations of eight human … my wifi turns off when i close the laptop lid