WebPaclitaxel is known as a chemotherapy drug that can suppress the proliferation of cancer cells by inducing cell cycle arrest and induction of mitotic catastrophe. However, today, it is well... WebAug 18, 2024 · Overexpression of ATP-binding cassette drug efflux transporters (ABC transporters, such as ABCB1 or MDR1) on the plasma membrane of cancer cell lines, isolated as paclitaxel- or olaparib-resistant cells, has been regarded as a mechanism of drug resistance toward relatively lipophilic anti-cancer drugs, such as doxorubicin, …
Second-line weekly paclitaxel in resistant or relapsed …
WebOne cell line showed moderate resistance to paclitaxel relative to pseudodiploid cells but significantly less resistance than its trisomy 3 prexenograft counterpart (about 7.8% more living cells in the 3-3 p.x. 1 cell line than wild-type [WT] p.x. 1 compared to 27.9% more surviving cells in the true trisomy 3 cell line than in wild type; see SI … WebThe SKOV-3 ovarian serous carcinoma cell line, which has inducible expression of dominant negative Nac1, was used to determine the paclitaxel treatment associated … shortcut to open notepad in windows 10
Paclitaxel (Taxol®) Mechanisms of Resistance
Web58 rows · BMS-184476 is a novel taxane (methylthiomethyl ether of paclitaxel) active against paclitaxel-resistant cell lines with the multidrug resistance phenotype that … WebAug 4, 2024 · We generated models of acquired paclitaxel resistance from the human clear cell ovarian carcinoma cell line, TOV-21G, and the human papillary serous ovarian … WebJul 6, 2024 · The paclitaxel-resistant cell line, PTX1 was established from paclitaxel-sensitive USPC1 cells. To generate paclitaxel-resistant cells, USPC1 cells were continuously exposed to doses of paclitaxel half-maximal inhibitory concentration (IC50) … shortcut to open previously closed tab