Lithoplocamia lithistoides

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August undefined, 2024

WebGlobal Biodiversity Information Facility. Free and Open Access to Biodiversity Data. WebLithoplocamia lithistoides Dendy, 1922 (type by monotypy) Parent Plocamioninae Hooper, 2002 Orig. name Lithoplocamia Dendy, 1922 Synonymised names Monectyon Lévi & …

Lithoplocamia lithistoides - Wikipedia

Web1 nov. 2024 · Plocabulin, a marine natural polyketide isolated from the sponge Lithoplocamia lithistoides, is a novel and potent microtubule-destabilizing agent. Guided by the reported binding mode, several new analogs of plocabulin have been designed through removing the right aliphatic chain and further modifying on the group and the … WebLithoplocamia lithistoides (Q2418850) From Wikidata. Jump to navigation Jump to search. species of sponge. edit. Language Label Description Also known as; English: … chinese buffet rumford ri

Lithoplocamia - Unionpedia

Web1 apr. 2014 · Abstract. PM060184 belongs to a new family of tubulin-binding agents originally isolated from the marine sponge Lithoplocamia lithistoides. This compound … WebLithoplocamia lithistoides is een spons soort in de taxonomische indeling van de gewone sponzen (Demospongiae). Het lichaam van de spons bestaat uit kiezelnaalden en sponginevezels, en is in staat om veel water op te nemen. De spons behoort tot het … chinese buffet rowlett tx

Natural Products as Sources of Anticancer Agents

Lithoplocamia - Wikipedia

Web17 mrt. 2024 · Plocabulin (PM060184/PM184, PharmaMar) is a compound of marine origin derived from the Madagascan sponge Lithoplocamia lithistoides. Plocabulin belongs to a family of tubulin-binding agents that inhibits tubulin polymerization by binding to the dimer’s end, with one of the highest known affinities among tubulin-binding agents. Web11 dec. 2024 · At difference with the above cited phase II anticancer drugs, plocabulin (PM060184) is not an ADC but it is a Lithoplocamia lithistoides sponge-derived polyketide which acts as a very potent antimitotic agent, binding to a specific β-tubulin site with possible activity on tumors resistant to other tubulin inhibitors . grand elk golf course granby coloradoWebPM050489 is an effective polyketone inhibitor of Microtubule/Tubulin that can be isolated from Madagascan sponge Lithoplocamia lithistoides. PM050489 inhibits mitosis with an IC50 value of 26.4 nM. PM050489 has antitumor activity and can be used in cancer research [1] [2] . PM050489 inhibits the activity of HT-29, A-549 and MDA-MB-231 cells ... grand elk golf course review

"WebOvarian cancer (OC) is a life-threatening tumor and the deadliest among gynecological cancers in developed countries. First line treatment with a carboplatin/paclitaxel regime is initially... " - Lithoplocamia lithistoides

Lithoplocamia lithistoides

WebLithoplocamia lithistoides. Lithoplocamia lithistoides adalah spesies spons yang tergolong dalam kelas Demospongiae. Spesies ini juga merupakan bagian dari genus Lithoplocamia dan famili Raspailiidae. Nama ilmiah spesies ini pertama kali diterbitkan pada tahun 1922 oleh Dendy. Seperti spons pada umumnya, spesies ini memiliki tubuh … Web1 nov. 2024 · Plocabulin, a marine natural polyketide isolated from the sponge Lithoplocamia lithistoides, is a novel and potent microtubule-destabilizing agent. …

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Web1 dec. 2015 · PM050489 is a tubulin-binding agent originally isolated from the marine sponge Lithoplocamia lithistoides. This compound binds with very high affinity to β-tubulin at a new site, disrupting the microtubule network and impairing its function during divison, which leads to mitotic aberrations. WebLithoplocamia lithistoides is 'n sponsspesie in die taksonomiese indeling van die Demospongiae . Die liggaam van die spons bestaan uit kieselnaalde en sponginevesels en is in staat om baie water op te neem.

Web1 nov. 2024 · Plocabulin, a marine natural polyketide isolated from the sponge Lithoplocamia lithistoides, is a novel and potent microtubule-destabilizing agent. … WebOriginally isolated from the Madagascan marine sponge Lithoplocamia lithistoides, plocabulin is now obtained by total synthesis [3]. Plocabulin binds tubulin with high a nity, reducing its polymerization and depolymerization to a similar extent and thereby inhibiting microtubule dynamicity (Figure1) [4–6].

WebLithoplocamia is een geslacht van sponsdieren uit de klasse van de Demospongiae . For faster navigation, this Iframe is preloading the Wikiwand page for Lithoplocamia . Home Webde Voogd, N.J.; Alvarez, B.; Boury-Esnault, N.; Carballo, J.L.; Cárdenas, P.; Díaz, M.-C.; Dohrmann, M.; Downey, R.; Hajdu, E.; Hooper, J.N.A.; Kelly, M.; Klautau ...

• Lithoplocamia atlantica (Lévi & Vacelet, 1958) • Lithoplocamia dolichosclera Lévi & Lévi, 1983 • Lithoplocamia indica Pulitzer-Finali, 1993 • Lithoplocamia lithistoides Dendy, 1922

Web7 dec. 2024 · Plocabulin (PM184; Fig. 8) and its chloro-derivative (Fig. 8; PM-050489) were isolated by PharmaMar scientists from the sponge Lithoplocamia lithistoides, but due to the low levels in the extract, both … chinese buffet rock springs wyWebGenus: Lithoplocamia Species (6): L. atlantica – L. dolichosclera – L. indica – L. lithistoides – L. minor – L. tuberculata. Name . Lithoplocamia Dendy, 1922 References … chinese buffet saginaw miWebLithoplocamia is een geslacht van sponsdieren uit de klasse van de Demospongiae (gewone sponzen). 7 relaties: Lithoplocamia atlantica , Lithoplocamia dolichosclera , … chinese buffet salt lakeWeb21 jul. 2024 · Sponge: Lithoplocamia lithistoides PM060184 C 31H 45N 3O 7 Inhibits tubulin polymerization, which reduces microtubule dynamicity, and inhibits cell migration (),,,, Natural Products of Marine Origin for the Treatment of Colorectal and Pancreatic Cancers: Mechanisms and Potential ... grand elk railroadWebPHASE I STUDIES First-in-human phase I study of the microtubule inhibitor plocabulin in patients with advanced solid tumors Elena Elez1 & Carlos Gomez-Roca2 & Arturo Soto Matos-Pita3 & Guillem Argiles1 & Thibaud Valentin2 & Cinthya Coronado3 & Jorge Iglesias3 & Teresa Macarulla1 & Sarah Betrian2 & Salvador Fudio3 & Katrin Zaragoza3 & Josep … chinese buffet sanduskyWebLithoplocamia Click on organism name to get more information. Lithoplocamia lithistoides Disclaimer: The NCBI taxonomy database is not an authoritative source for nomenclature or classification - please consult the relevant scientific literature for the most reliable information. Reference: ... grand elk ranch granby coWebLithoplocamia lithistoides adalah spesies spons yang tergolong dalam kelas Demospongiae. Spesies ini juga merupakan bagian dari genus Lithoplocamia dan famili … chinese buffet salisbury md