WebApr 16, 2002 · Q13568 · IRF5_HUMAN Protein Interferon regulatory factor 5 Gene IRF5 Status UniProtKB reviewed (Swiss-Prot) Organism Homo sapiens (Human) Amino acids … WebIRF5 resides in the cytoplasm of most unstimulated cells and becomes activated by posttranslational modifications that include phosphorylation, acetylation, and/or ubiquitination, resulting in translocation to the nucleus ( 2, 13, 18 – 22 ).
Inhibition of IRF5 cellular activity with cell-penetrating peptides ...
WebMay 19, 2024 · IRF5 is activated by phosphorylation and ubiquitination events downstream of pattern recognition receptors (PRRs), e.g., nucleotide-binding oligomerization domain-containing protein 2 (NOD2), Toll-like receptor 2 (TLR2), and TLR4, and directly regulates many cytokines associated with IBD (IL-1β, IL-6, IL-10, IL-12, IL-23, and TNF), placing IRF5 … WebThe IRF5 protein from these reaction mixtures was further purified and analyzed by mass spectrometry, which revealed that peptides containing phosphorylated Ser-445 and Ser-434 of mIRF5 were greatly enriched in the reactions that contained IKKβ, whereas the total counts of mIRF5 peptides were similar in both reactions ( Fig. 3 B and C and Fig. S2 … dying career you may want to steer clear of
Activation and function of interferon regulatory factor 5
WebHere, we designed antagonistic cell-penetrating peptides (CPPs) by incorporating the native amino acid sequence of IRF5 to directly interrogate the mechanism (s) of IRF5 activation and function in human primary immune cells. RESULTS Identification of novel CPP motifs and design of CPPs targeting IRF5 WebMar 21, 2024 · IRF5 (Interferon Regulatory Factor 5) is a Protein Coding gene. Diseases associated with IRF5 include Systemic Lupus Erythematosus 10 and Inflammatory Bowel Disease 14 . Among its related pathways are Toll-like receptor signaling pathway and Interferon gamma signaling . WebApr 17, 2007 · These alterations in IRF5 protein structure and expression levels presumably shape the IRF5 transcriptional cascade and downstream immune responses. It has been shown that IRF5 is activated by Toll-like receptors 7/9 and type 1 IFN signaling and that, upon stimulation, different IRF5 protein isoforms differentially activate transcription of ... crystal red tintcoat paint