WebAug 11, 2004 · In the cytoplasmic compartment, transient spots of fluorescence emission from substrate molecules were occasionally observed. However, such events were rare (0.0074 ± 0.0018 events per s per μm 2 ), as is expected from molecules that are free in solution and thus diffuse micrometer-scale distances on the time scale of a single video … WebNov 1, 2009 · ATPase activity and substrate selection of AAA+ proteins are regulated by adapter proteins that bind to regulatory domains, such as the N-terminal domain (NTD). …
A spatial model of YAP/TAZ signaling reveals how stiffness ... - PNAS
WebDec 24, 2024 · The membrane-spanning region of the ABC transporter protects hydrophilic substrates from the lipids of the membrane bilayer thus providing a pathway across the cell membrane. In gram-negative bacteria, exporters transport lipids and some polysaccharides from the cytoplasm to the periplasm. Eukaryotes do not possess any importers. WebOct 21, 2008 · Using an unbiased quantitative proteomics approach, novel substrate targets for the protease γ-secretase are identified and analyzed to determine which domains enable their cleavage. ... because the γ-secretase substrate desmoglein-2 contains a cytoplasmic domain of similarly large size (Figure 3F). how to search in diigo by date
Ubiquitin signals autophagic degradation of cytosolic proteins ... - PNAS
WebDec 30, 2008 · Here, we report a general mechanism for substrate-specific autophagy that involves ubiquitin and the ubiquitin-binding protein, p62. We showed that when long-lived cytoplasmic substrates (including RFP and peroxisomes) were linked to ubiquitin, they became selectively sequestered and degraded by the autophagic pathway. WebApr 30, 2024 · cGAS (also known as C6orf150, or male abnormal 21 domain containing 1 (MAB21D1)) is located on chromosome 6q13 and encodes a protein with 522 amino … WebFeb 9, 2006 · The carriers exist in two distinct conformational states: the cytoplasmic state ( c -state) in which the carrier accepts its substrate from the cytoplasm, and the matrix state in which it accepts a substrate from the mitochondrial matrix. For the ADP/ATP carrier, the inhibitor carboxyatractyloside (CATR) is known to bind to the carrier in the c ... how to search index 2 online