WebHere, we report an efficient chemoenzymatic method that permits highly site-selective enzymatic glycoengineering of both Fc and Fab glycans of cetuximab, a chimeric mouse-human anti-epidermal growth factor receptor (anti-EGFR) therapeutic antibody used for the treatment of colorectal cancer and squamous-cell car-cinoma of the head and neck (21). WebBy chemoenzymatic glycoengineering with Endo-M and Glycosynthase, heterogenous N-linked oligosaccharides attached to an antibody are replaced by fine-defined, an oligosaccharide with focused substrate specificity toward non-corefucosylated biantennary N-glycan. 7) First, Endo-M hydrolyses a glycoside-bond of chitobioses linked to N-glycan …
Importance and Monitoring of Therapeutic Immunoglobulin G …
WebJul 25, 2012 · The glycoengineering approach described here provides a general platform to modulate the effector functions of IgG antibodies, enabling the optimization of therapeutic efficacy and gain of new functions of monoclonal antibodies and IVIG. Publication types Research Support, N.I.H., Extramural MeSH terms Amino Acid Sequence WebAbstract At present, numerous studies have been reported to remodel the N -glycans of therapeutic antibodies for the gain of functions. Among the ways of remodeling antibody … how to highlight a trace in altium
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